The four most harmful drugs in the kidney

By | July 13, 2019

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Avoid drug combination, check kidney function regularly

As the saying goes, “Men are afraid of hurting the liver, women are afraid of hurting the kidney”, the fact is not limited to this, as the human body The basic organs that the metabolism relies on, the kidneys are very important for men, women and children. It is worth noting that in recent years, the trend of increasing kidney disease year by year is very obvious, and a large part of it is related to improper use of drugs.

The kidneys of the elderly gradually shrink, the function gradually declines, and the renal blood flow decreases. Children’s kidney function is not fully developed. Therefore, drug-induced renal damage is particularly likely to occur among elderly and children. In addition, patients with renal dysfunction, allergic, dehydrated patients are also prone to drug-induced renal damage, especially in patients with two or more nephrotoxic drugs at the same time, the incidence of kidney damage is even more high. Once drug-induced renal damage occurs, it will seriously affect the patient’s physical health, but it will damage the kidney function and induce nephritis; in the case of kidney necrosis, acute or chronic renal failure, it may even cause death, and must be vigilant.

The main drugs that cause kidney damage are:

Aminoglycoside antibiotics: such as gentamicin, kanamycin and so on. After the use of these drugs for more than 10 days, the incidence of kidney damage will increase significantly.

Quinolones: such as norfloxacin, ciprofloxacin, ofloxacin, etc. Once the dose of these drugs is too large, it will cause hematuria, interstitial nephritis, and severe cases will lead to acute renal failure.

Sulfonamides: If compound sulfamethoxazole is easy to produce crystals and cause obstructive nephropathy, hematuria, renal colic, and even acute renal failure, especially in dehydrated and elderly patients, are more likely to occur. Therefore, you should drink more water when taking these drugs, and take sodium bicarbonate (baking soda) tablets to alkalinize urine to reduce damage to the kidneys.

Contrast agent: It is a widely used drug in recent years, and acute renal damage caused by it is more and more common. The hypertonicity of the contrast agent can aggravate renal ischemia and can also directly cause toxicity to the kidneys. Because the contrast agent is an allergen, it can cause a systemic allergic reaction and affect the kidneys.

In addition, diuretics such as hydrochlorothiazide and furosemide have potential nephrotoxicity, and high-dose intermittent therapy or re-administration of rifampicin after discontinuation may also induce acute interstitial nephritis and acute tubules. Kidney diseases such as necrosis have to be taken care of.

Generally speaking, too much dose and long course of treatment are the main causes of kidney damage after medication. Therefore, when taking the above drugs, the first principle is to insist on rational drug use and avoid drug abuse. At the same time, try to avoid the combination of two or more nephrotoxic drugs. For high-risk groups, adjust the dosage and medication according to the state of renal function.

In addition, patients should often have a renal function test when using the drug in order to detect the early manifestations of drug-induced nephropathy. If you find signs of kidney disease such as backache weakness, abnormal urine, edema of the limbs, fatigue, and increased blood pressure, you should stop the drug or adjust the dosage in time to minimize the deterioration of drug-induced nephropathy.

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